Research Technician - Wucherpfennig Lab

Location US-MA-Boston
Job Posted Date 2 weeks ago(2/7/2018 5:57 PM)
Job ID
Hidden (24988)
full time


Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

This position will assist in performing scientific research tasks of varying complexity in the Wucherpfennig lab, whose research focuses on the development of novel immunotherapies for cancer. In general, this position will assist in the set-up, operation and maintenance of laboratory instruments and equipment, monitoring experiments, making observations and calculating and recording results.


Specifically, the lab has developed a novel approach to discover therapeutic targets in vivo in the relevant tissue microenvironment. Cytotoxic T cells have the ability to specifically eradicate cancer cells but are frequently inhibited within tumors. We have developed a novel RNAi-based approach to discover key genes that regulate T cell function in cancers. The work involves characterization of such candidate genes and evaluation of their therapeutic potential.



This position involves isolation of T cells from mouse models, introduction of lentiviral vectors and ex vivo characterization and purification of T cell populations by flow cytometry. General daily responsibilities listed below. 

    • Set up, adjust, calibrate, clean, maintain and troubleshoot equipment.
    • Clean, maintain and prepare supplies and work areas and may be responsible for ordering of supplies. Collaborates with Purchasing and may be responsible for negotiating with vendors.
    • Conduct standardized biological, microbiological or biochemical tests and laboratory analyses, including the collection of information and samples from organic substances, such as blood, drugs, and animals.
    • Isolate, identify and prepare specimens for examination.
    • Analyze experimental data and interpret results to write reports and summaries of findings, including grant preparation and presentations, and look for opportunities to co-author publications. May be expected to participate in formal and information presentations of results to staff.
    • Maintains detailed notebook of all work-related activities.
    • Monitors laboratory work to ensure compliance with Environmental Health and Safety information as well as the standard operation procedures specific to each laboratory.
    • Expected to provide intellectual and interactive commitment to position by keeping up with appropriate literature and research publications.
    • May be responsible for the development, modification and improvement of standard operating procedures.
    • Uses computers, computer-interfaced equipment, robotics or high-technology applications to perform work duties.
    • May be responsible for designing and executing advanced experiments and setting strategy.
    • May be responsible for the examination of animals and specimens to detect the presence of disease or other problems.
    • Helps keep spaces tidy including areas communal areas after lab meeting and other group meetings.


The position is open to recent college graduates as well as more experienced applicants. Requirements are a Bachelor’s Degree in biology, chemistry, or a related field of science; prior experience in molecular biology, cell culture and/or flow cytometry is a plus.  To learn more about our lab, please visit our website:


Additional qualifications:

  • Must have excellent communication skills (written and verbal) and be able to work with a wide variety of faculty and staff.
  • Ability to analyze information and use logic to address work-related issues and problems.
  • Must have attention to detail and be thorough in completing work tasks.
  • Ability to work within a team environment.

If interested, please apply and include:

Cover Letter explaining your past experiences and interests.


Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.


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