Scientist - Center for Cancer Precision Medicine

Location US-MA-Boston
Job Posted Date 3 weeks ago(1/29/2018 11:12 AM)
Job ID
Hidden (24997)
full time


Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

The Center for Cancer Precision Medicine (CCPM) is a major institutional priority, being established across Dana-Farber Cancer Institute (DFCI), Brigham & Women’s Hospital (BWH), and the Broad Institute (Broad). The mission of this Center will be to catalyze the implementation and innovation of precision cancer medicine and medical science at these institutions. The Center will leverage a multitude of existing and new capabilities for comprehensive genomic characterization, computational analysis, and technology development. It will bring together DFCI and BWH resources to pioneer new approaches for tissue biopsies, with the goal of facilitating the generation and clinical interpretation of tumor molecular data from clinical trials. CCPM will integrate and coordinate various research and clinical disciplines, and establish joint capabilities across BWH, DFCI, and the Broad with the ultimate goal of creating a leading cancer precision medicine research enterprise.



Position Summary


The CCPM Innovation Lab is seeking a PhD-level research scientist to lead a team, which performs studies focused on understanding the mechanisms of therapeutic response and resistance in cancer. The ideal candidate will develop and implement methods that augment cancer precision medicine. The research scientist will design and perform systematic or hypothesis-directed studies of tumor cell populations, genetic alterations and other molecular features that may inform clinical decision-making, resistance mechanisms or treatment response. These studies may include optimizing protocols for characterizing single cells isolated from clinical samples as well as establishing methods for the propagation and perturbation of patient-derived tumor/normal cell lines. This individual will be responsible for collecting, analyzing and interpreting data, designing and conducting follow-up experiments and preparing publications.


Roles and Responsibilities

  • Optimize and implement tissue dissociation and preparation of clinical samples, immuno-staining, flow-cytometry and single cell characterization.
  • Established conditionally reprogrammed cancer/normal cell lines for use in cell-based assays.
  • Perform a variety of cancer biology assays; including cell growth, apoptosis, drug sensitivity and mechanism of action assays.
  • Use lentiviral transduction techniques to generate cell lines that overexpress proteins (ORFs) or are deficient or mutant for targeted proteins (CRISPR/Cas9).
  • Participate in writing protocols and SOPs for the development of new methods and technologies.
  • Critically read and interpret the scientific literature and significantly contribute to scientific direction, publications and presentations.
  • Participate in formal and informal presentations of results.


  • PhD in cancer or molecular biology.
  • Extensive hands-on research experience and outstanding technical and innovative skills.
  • Sound scientific approach to experimental design, data analysis and interpretation.
  • Must be reliable, organized, and able to work independently as well as with other members of CCPM and the Broad Institute.
  • Possess strong communication and interpersonal skills and be highly motivated to contribute to the discovery of new medicine to impact cancer care.
  • We are looking for candidates who have at least two years of availability. 

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.


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