Research Fellow

Location US-MA-Boston
Job Posted Date 3 weeks ago(1/31/2018 9:59 AM)
Job ID
full time


Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.


Donald Kufe, M.D.'s laboratory in the Division of Molecular and Cellular Biology and the Department of Medical Oncology at the DFCI focuses on the role of the MUC1-C oncoprotein in human cancers.


MUC1-C is aberrantly overexpressed in diverse carcinomas and is associated with poor clinical outcomes.


Emerging work has shown that MUC1-C regulates the epigenome of human cancer cells and thereby orchestrates gene expression programs linked to carcinogenesis.


These findings have uncovered a new dimension for the function of MUC1-C in chromatin construction and have opened new avenues for discovery.


Dr. Kufe is seeking a qualified postdoctoral candidate interested in studying the effects of MUC1-C on local and three-dimensional chromatin structure.


A high priority will be placed on experience with ChIP-seq, hi-C, RNA-seq and analysis of bioinformatic data. 


The successful candidate will be expected to lead and develop independent projects and work in conjunction with other post-doctoral fellows in the Kufe laboratory.


The candidate must have a MD, PhD or MD/PhD with several years of relevant experience in the epigenetic regulation of cancer cells. 


The ideal candidate should also have a strong background in the molecular biology of genetically modified human cancer cells.


Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.





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