Lead Research Technician - Armstrong Lab

Location US-MA-Boston
Job Posted Date 6 months ago(8/30/2017 3:26 PM)
Job ID
Hidden (24988)
full time


The lab of Dr. Scott Armstrong, Chair of the Department of Pediatric Oncology, and the Center for Pediatric Cancer Therapeutics are seeking outstanding applicants for a Lead Research Technician to support our pre-clinical research activities. Our research focuses on identifying new treatment approaches for pediatric patients with cancer. The laboratory uses a variety of genomic, epigenomic, and chemical biology approaches to characterize the mechanisms that control pediatric cancer development and identify new therapeutic targets. The lead research technician will work with in vivo models of pediatric cancers to validate new therapeutic candidates for leukemias and solid tumors. The candidate will interact and collaborate closely with other laboratory-based scientists across the Center, Armstrong lab and Dana-Farber Cancer Institute.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.


  • Developing/determining methods and procedures for new pre-clinical research assignments; may coordinate activities of junior staff
  • Executing pre-clinical in vivo mouse studies with novel therapeutic agents in PDX, xenograft, and genetically-engineered models of cancer
  • Performing general mouse colony husbandry, breeding, genotyping, etc., as necessary
  • Independently executing cell and molecular biology techniques including FACS, PCR, sterile tissue culture, DNA/RNA isolation and gene expression analysis (qPCR and preparing samples for RNA-seq).
  • Ordering, preparing and maintaining stocks of necessary reagents, solutions, and supplies
  • Documenting, compiling, and analyzing experimental data
  • Effectively reporting data in written and oral formats
  • Participating in all Center planning meetings


  • Bachelor’s/Master’s degree in Biology or related field
  • Minimum of 4-6 years of related experience in a scientific or medical research setting is required
  • Animal handling experience is required. Mouse colony breeding and husbandry, genotyping, drug administration (oral gavage and injections – IP, subQ and IV) is preferred. Proficiency in mouse tumor models is preferred. 
  • Molecular biology techniques including PCR, qPCR, sterile tissue culture, DNA /RNA isolation and analysis is preferred
  • Experience with FACS is preferred
  • Familiarity with basic and more senior level laboratory techniques required
  • Requires a working knowledge of basic computer skills, including word processing, spreadsheets, and other related software 
  • Effective communication skills, both written and oral
  • Strong organizational techniques, including the ability to handle a variety of tasks in a fast-paced environment

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.


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