Dana-Farber Cancer Institute

Returning Candidate?

Research Fellow

Research Fellow

Job ID 
full time
Job Posted Date 

More information about this job


Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.


The Buhrlage and Dhe-Paganon laboratories at the Dana-Farber Cancer Institute are seeking a highly-motivated full-time Post Doctoral Fellow who will lead and execute a structure-guided drug-discovery project focused on deubiquitinating enzymes. The ideal candidate will have expertise in biochemistry, biophysics, and structural biology, with specific applications such as screening, hit validation, mechanism of action studies, and structure-determination. The successful candidate will work with an interdisciplinary team including medicinal chemists, structural biologists, and physiologists to discover and develop inhibitors, chemical probes, and drug candidates (see for example Ritorto et al., Nat Commun. 2014 Aug 27;5:4763 and Tanaka et al., Nature Chem Bio 2016, 12(12):1089-1096). 

Protein expression and purification; biochemical, biophysical, and structural characterization of small molecule ligand interactions; mentoring junior lab members; maintaining a detailed laboratory notebook



Ph.D. Degree with experience in biochemistry, biophysics, and crystallography.


Please send CV, a brief summary of research experience and names of three referees to: Sara Buhrlage, Department of Cancer Biology, Dana-Farber Cancer Institute; email: dhepag@crystal.harvard.edu and saraj_buhrlage@dfci.harvard.edu


Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.

Connect With Us!

Not ready to apply? Connect with us for general consideration.