Senior Research Technician - Marasco Lab

7 months ago
Job ID
Hidden (24988)
full time


Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.


The Marasco lab is seeking a highly motivated, bright individual to join its research team as a Senior Research Technician who will be primarily involved in cancer immunotherapy studies including in vitro molecular biology and immunology studies and in vivo small animal experiments that are critical to ongoing research projects in the lab.  


The Marasco Laboratory is located in the Department of Cancer Immunology and Virology at Dana-Farber Cancer Institute. Our general research interests are in the field of targeted immunotherapy. The Lab’s work has made major scientific advances in the treatment of cancer and infectious diseases.  More recently, we have been developing humanized mice to support our targeted immunotherapy studies and to investigate the roles of human adult stem cells in regenerative medicine.  Please visit



Responsibilities include but are not limited to performing in vitro molecular cloning, protein (Ab or Ag) expression/purification, CAR-T cell generation, and anti-tumor cell killing studies.  The successful technician will assist breeding colony management, injections (IV, IP, SC, IM, ID), blood sampling techniques (sub-mandibular and cardiac puncture), necropsy, immunization, tumor measurements, and gamma irradiation for research animals.


A basic knowledge in molecular and cellular biology and immunology is desired as this person will be expected to contribute significantly toward developing research projects and performing immunoassays with minimal supervision. S/he will also be constructing and maintaining specialized "humanized" mice developed in-house.  As such, experiences in tissue procurement and processing including stem cell purification, small animal survival surgery, and isolation/characterization of human and mouse lymphocytes are definite plus. Other duties include:

-  Assist, train or supervise other lab members on animal experiments

-  Perform standard molecular biology assays, cell culture and flow cytometry.

-  Document, compile, and assist in interpreting experimental data. Report data to supervisor in oral and written reports and give presentation at group meetings. Construct figures for grant proposals, progress reports and manuscripts.

-  Independently operates lab equipment, prepares and orders necessary supply stocks. Shares lab maintenance duties with other lab members.  



This is a regular, full time position.  Nights and weekends may be required to meet research needs.



-  Bachelor’s degree or higher in biological sciences or related field.

-  Self starter, highly motivated team player and ability to multi-tasking

-  Proficiency in basic lab techniques and principles of molecular biology and immunology required

-  2-3 years of experience in animal handling while working in a biomedical research laboratory is preferred

-  Proficiency in the use of various scientific databases and publications is required.

-  Excellent written and oral communication skills as well as strong organizational skills required. 

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.


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