Senior Research Fellow in Structural Biology - Marasco Lab

7 months ago
Job ID
full time


Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.


The Marasco Lab in the Department of Cancer Immunology and Virology at the Dana-Farber Cancer Institute is seeking a Senior Fellow or an entry level Scientist with training in structural biology.  We are a human therapeutic monoclonal antibody engineering laboratory and are working to isolate broadly neutralizing human monoclonal antibodies against influenza A and B.  As part of this effort, we are focused on solving co-crystal structures of mAbs and influenza A hemagglutinin (HA) and neuraminidase (NA).  We combine this information with virus neutralization escape studies to better predict which epitopes on these two viral glycoproteins should be targeted for universal influenza vaccine development.  This individual may also be involved with the designs of novel universal influenza vaccines based on structural analysis and in silico modeling.  S/he will express HA/NA proteins from baculovirus infected insect cells and form complexes with Fab fragments for co-crystallographic studies. For novel vaccine designs, the recombinant viral proteins will be used for functional binding studies with panels of mAbs to map the integrity of the neutralizing epitopes. The candidate must be a self-starter and highly motivated team player.  S/he is expected to be fully involved in hands-on bench work, able to work independently, well versed in the related literature, and contribute intellectually to her/his research program. The individual is also expected to be able to parallel processing (good time management skills), well organized, and pay careful attention to experimental details.  The successful candidate may also have the opportunity to become involved in structural studies with other emerging pathogens.


Requirements:  PhD with 2 years proven research expertise in structural biology.  The ideal candidate should have a solid knowledge and demonstrable expertise in molecular biology and immunology, especially in antibody and/or viral protein structures.


Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.


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