• Scientist I

    Location US-MA-Boston
    Job Posted Date 1 year ago(6/1/2017 12:28 PM)
    Job ID
    Hidden (24997)
    full time
  • Overview

    Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.


    The Fischer lab studies the Ubiquitin Proteasome System (UPS). Using structural biology, cell biology and biochemical approaches, we address the molecular workings of multi-component ubiquitin ligases, and their roles in normal and disease processes. In addition, we are investigating the therapeutic potential of targeting the UPS with small inhibitory molecules. This position will be required to exercise sound judgment for the execution of complex experimental programs, and the resolution of critical experimental challenges.  It will manage and mentor multiple laboratory personnel, and have wide latitude in decision-making. The role will require development, execution and oversight of biochemical and cellular assay systems for profiling of novel small molecules.


    We are seeking candidates with a PhD and extensive experience in at least one of the following: biochemical and cellular assay development, enzymology, biochemical and biophysical characterization of protein-protein and protein ligand interactions. Demonstrated successes in technical proficiency, scientific creativity, collaboration, independent thought, and strong leadership are required.


    Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.


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