• Scientist I

    Location US-MA-Boston
    Job Posted Date 2 weeks ago(10/4/2019 8:47 AM)
    Job ID
    2020-17204
    Category
    Research- Laboratory
    Type
    full time
    Grade
    45
  • Overview

    The Fischer Lab at Dana-Farber Cancer Institute is a Structural Biology Lab that combines molecular biology, computational biology, structural biology and chemistry with various ‘Omics’ techniques to study the pathways and protein complexes involved in the regulation of protein abundance via cellular degradation systems that are often associated with human diseases, including cancer. Using our knowledge of the cellular degradation machinery, we use structure and computational guided approaches to develop new molecules that hijack the ubiquitin proteasome system for targeted protein degradation.

    The Ebert laboratory studies the genetics, biology, and therapy of myeloid malignancies.  Studies on the mechanism of action of lenalidomide, a drug with efficacy in multiple hematologic malignancies, revealed that lenalidomide and related compounds act by modulating the function of an E3 ubiquitin ligase, resulting in the drug-induced degradation of key therapeutic targets.  The laboratory uses genetic screens, proteomics, and molecular biology studies to characterize new molecules and substrates of targeted protein degradation.

    The Fischer (https://fischerlab.dana-farber.org/) and Ebert labs (https://ebertlab.dana-farber.org) seek a highly motivated individual to join the team as a RESEARCH SCIENTIST who will develop mass spectrometry methods and collaborate with scientists, postdocs and students in the lab on research projects focused on targeted protein degradation as a novel therapeutic modality. While we consider various mass spectrometry related backgrounds, a strong interest and understanding of mass spectrometry-based proteomics is a must and strong computational skills are highly desirable.

    Our laboratories are based at Dana-Farber Cancer Institute in Longwood Center and affiliated with Harvard Medical School. We are further affiliated with state of the art facilities for structural biology (cryo-EM, X-ray crystallography, NMR), chemistry, biophysics, cellular imaging, etc. and the lab has expertise and equipment for mass spectrometry including Orbitrap Lumos tribrid mass spectrometers. Join our highly interactive team of scientists, postdocs, graduate students and technicians to work on understanding signaling through the ubiquitin proteasome pathway and leverage these insights to test new avenues for therapeutic development.

     

    Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world-renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

    Responsibilities

    • Proteomics-based method development
    • Analyze experimental data and interpret results to write reports, presentations, grant and publication preparation
    • Maintains detailed notebook of all work-related activities
    • Collaborates with other lab members for the development, modification and improvement of standard operating procedures

    Qualifications

    • Recent Ph.D. or equivalent degree in biochemistry, analytical chemistry or mass spectrometry and significant post-PhD research experience
    • Strong understanding of statistical and computational methods
    • Experience in sample preparation for mass spectrometry-based proteomics
    • Ability to collect and analyze experimental data, prepare research publications and communicate results
    • Ability to work in a collaborative and team environment
    • Excellent oral and written capabilities
    • Experience with R, MATLAB, or python and general computational abilities

     

    Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.

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