• Research Technician

    Location US-MA-Boston
    Job Posted Date 4 months ago(11/4/2019 7:01 PM)
    Job ID
    Research- Laboratory
    full time
    Location : Address
    450 Brookline Ave
    Location : City
  • Overview


    We are seeking a highly-motivated and skilled Research Technician who will be responsible for providing high-level technical support for ongoing research efforts in Dr. Nathanael Gray’s lab (https://graylab.dana-farber.org/). The goals of our research program are to advance a large portfolio of small molecule inhibitors and degraders targeting cancer drivers to gain new biological insights and pharmacologically validate targets. This is an exceptional opportunity to join a team that is pushing the boundaries of targeted protein degradation research and accelerating the translation of basic science into clinical solutions. Join our highly interactive team of scientists and technicians to work on testing and creating new avenues of therapeutic intervention.


    We are seeking applicants to contribute to both conceptual and technical aspects of the project and assist scientists in performing scientific research, development and/or clinical tasks of varying complexity. The applicant will perform independent studies to evaluate small molecule inhibitors degraders in cancer model systems as well as assist in the set-up, operation and maintenance of laboratory instruments and equipment, monitoring experiments, making observations and calculating and recording results. The applicant should be able to work independently and be comfortable problem solving.


    • Molecular biology techniques including western blotting, PCR, qPCR, sterile tissue culture, cloning, DNA/RNA isolation, CRISPR/Cas9-mediated genome editing experiments, flow cytometry, and cell sorting.
    • Conduct standardized biological, microbiological or biochemical tests and laboratory analyses, including the collection of information and samples from organic substances, such as blood, drugs, and animals.
    • Isolate, identify and prepare specimens for examination.
    • Set up, adjust, calibrate, clean, maintain and troubleshoot equipment.
    • Analyze experimental data and interpret results to write reports and summaries of findings, including grant preparation and presentations, and look for opportunities to co-author publications.
    • Will be expected to participate in formal and information presentations of results to staff. 
    • May be responsible for designing and executing advanced experiments and setting strategy. 
    • Maintains detailed notebook of all work-related activities.
    • Participate in grant application process and manuscript preparation as required.
    • Clean, maintain and prepare supplies and work areas and may be responsible for ordering of supplies. Collaborates with Purchasing and may be responsible for negotiating with vendors.
    • Monitors laboratory work to ensure compliance with Environmental Health and Safety information as well as the standard operation procedures specific to each laboratory.
    • Expected to provide intellectual and interactive commitment to position by keeping up with appropriate literature and research publications.
    • May be responsible for the development, modification and improvement of standard operating procedures.
    • Uses computers, computer-interfaced equipment, robotics or high-technology applications to perform work duties.
    • May be responsible for the examination of animals and specimens to detect the presence of disease or other problems.
    • May be responsible for monitoring laboratory budgets.


    • Bachelor's Degree required with a major in biology, biochemistry or chemistry preferred.
    • MS in biology, or a related field, and/or at least 1-2 years of professional laboratory experience is a plus.
    • At least a two-year commitment preferred. 
    • Previous technical experience with basic cellular and molecular biology research techniques is required, including, but not limited to tissue culture, western blotting, immunoprecipitation, extraction and analysis of DNA and RNA, PCR, and cloning
    • Experience in bioinformatics and/or mouse modeling is a plus.
    • Good organizational and interpersonal skills and a working knowledge of data management, word processing, and graphic software (Excel, MS Word, Graphpad/PRISM) is preferred.
    • Some work on nights and weekends may be required.
    • Knowledge of information and techniques related to either biology, chemistry, or medicine is preferred.
    • Must have excellent communication skills (written and verbal) and be able to work with a wide variety of faculty and staff.
    • Ability to analyze information and use logic to address work-related issues and problems.
    • Must have attention to detail and be thorough in completing work tasks.
    • Ability to work within a team environment.


    Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.


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