• Computational Biologist, Pediatric Oncology (Crompton Lab)

    Location US-MA-Boston
    Job Posted Date 2 months ago(8/26/2019 12:10 PM)
    Job ID
    IT/Health IT/Informatics
    full time
  • Overview

    Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

    The Crompton Laboratory focuses on leveraging genomic and proteomic approaches to transform our understanding of the biology of pediatric solid tumors and identify novel treatment approaches for these diseases. We utilize high-throughput molecular profiling of tumors and liquid biopsy samples to understand how tumors evolve and how tumor heterogeneity contributes to the development of treatment resistance. Our laboratory is highly collaborative, working with leaders whose expertise span the spectrum of the oncology field from clinicians leading cutting edge therapeutic trials at Dana-Farber Cancer Institute to the scientific innovators who are developing the next-generation of laboratory technologies at the Broad Institute. We leverage these relationships to interrogate patient-derived samples in order to unravel the biology driving the most aggressive forms of pediatric cancers.

    We are recruiting a Computational Biologist who will be at the center of our genomic studies, analyzing data generated from unique patient sample cohorts with existing tools and developing novel computational algorithms for studies without established approaches.


    The Computational Biologist will work with sequencing data generated from tumor and cell-free DNA samples profiled with sequencing panels, whole-exome sequencing (WES), and whole-genome sequencing (WGS). Novel computational approaches will need to be developed that are optimized for the molecular hallmarks of pediatric solid tumors and the unique questions being asked in our experiments. The Computational Biologist will also be expected to adapt single-cell sequencing pipelines to analyze RNA-Seq, WGS, and ATAC-seq data generated from circulating tumor cells obtained from patients with pediatric sarcomas.

    While the Computational Biologist will be expected to have mastered coding languages and have a comfort with the mathematical/statistical approaches relevant to the analysis of genomic data, the candidate will also benefit from the rich scientific and computational environment of Dana-Farber Cancer Institute and the Broad Institute to learn specific techniques required for our projects.

    • Analyze next-generation sequencing data using existing pipelines
    • Develop new computational pipelines adapted to unique sample types and patient cohorts
    • Provide support for basic computational tasks in the lab
    • Document methods for reproducible analysis
    • Organize and visualize experimental results and effectively communicate those results through the preparation of material for oral presentations, manuscripts, and grant proposals
    • Participate in lab meetings and department meetings at Dana-Farber and the Broad Institute


    • Bachelor’s, Master’s, or Doctoral degree in Computer Science, Bioinformatics or related field, or equivalent relevant experience
    • Familiarity with coding in R or other data analysis / statistics-based language
    • Familiarity with coding in Python or other similar scripting language
    • Experience with analysis of genomic data
    • Experience with data summary visualization
    • Effective communication skills
    • Strong organizational techniques, including the ability to handle a variety of tasks in a fast-paced environment

    Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.


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