The laboratory of Dr. Pietro Genovese at the Dana-Farber Cancer Institute is seeking an energetic, efficient, and resourceful candidate with a strong propensity for team work, who will conduct a translational project focused on empowering adoptive cancer immunotherapy by precise genetic modification of human hematopoietic stem/progenitor cells and lymphocytes. The project will combine advanced genetic engineering tools with state-of-the-art preclinical animal models and will benefit from a highly integrated, multidisciplinary and supportive research environment, such as that of the Harvard Medical School.
The Genovese lab is a translational gene therapy research group that exploit a variety of cutting-edge gene editing technologies (CRISPR/Cas, TALEN, ZFN, base editors, epigenetic transcriptional regulators) to develop new therapeutic strategies for inherited and onco-hematologic diseases. They couple advanced molecular and cell biology approaches, such as viral vectors design, chimeric antigen receptors (CAR), next generation sequencing and ex vivo manipulation of stem cells and primary lymphocytes, with suitable preclinical models of disease to test novel therapeutics based on precision medicine both in vitro and in vivo.
The successful candidate will be a team player capable of handling multiple tasks and adaptable to a fast-paced research environment. We offer advanced training in scientific techniques and professional skills, provide mentorship and networking opportunities, actively support your career development, and assist you with raising funds for yourself and for your projects. This will ensure that you can work efficiently and are prepared for the next step in your career.
The Dana-Farber Cancer Institute (DFCI), located in Boston and the surrounding communities, brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.
The Genovese lab is part of the Dana-Farber/Boston Children’s Gene Therapy Program, one the most extensive and long-running pediatric gene therapy programs in the world, featuring a multidisciplinary team that includes physicians, nurses, researchers, clinical research coordinators, and program administrators. Because our team addresses the full spectrum of gene therapy from basic research to clinical treatment, our program is continually at the forefront of gene therapy care. Since 2010, we have treated 36 patients from 11 countries through eight gene therapy clinical trials.
The successful candidate will be primarily responsible for one project aimed at developing innovative gene therapy protocols for the treatment of inherited or acquired hematologic-disorders, such as primary immunodeficiencies or leukemias. Under the direct supervision of the PI, he/she will be responsible for designing, developing and implementing experimental protocols, working with animal models, mentoring and supervising undergraduate researcher assistants, present research results at national and international scientific meetings, preparing papers for publication, and writing grants.
In this competitive call, we are recruiting worldwide a talented, ambitious, self-motivated and team-oriented scientist with a recent PhD in life sciences, a strong background in immunology and/or cancer biology, and a strong interest in working with advanced molecular biology techniques, in vitro and in vivo tumor models and human samples.
Specific skills and personal attributes required include: high energy multi-tasker, supremely organized with exquisite attention to detail, exemplary communication skills, computer and technology savvy, strong expertise with molecular and cellular biology. Experience with immunology, next generation sequencing and/or mouse models will be an asset. Strong academic track record, including publications (published, submitted or in preparation) is required.
Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.