• Scientist – Chemical Biologist - Center for Protein Degradation

    Location US-MA-Boston
    Job Posted Date 4 weeks ago(2/3/2020 5:19 PM)
    Job ID
    Research- Laboratory
    full time
    Location : Address
    450 Brookline Ave
    Location : City
  • Overview



    Chemical Biologist (Scientist) – Center for Protein Degradation


    The Center for Protein Degradation (CPD) seeks a highly motivated individual to join the team as a SCIENTIST who will work on various projects focused on the development of therapeutic degrader molecules.


    Dana-Farber Cancer Institute (DFCI) and Deerfield Management have entered a collaboration to create the Center for Protein Degradation (CPD) at DFCI led by Nathanael Gray, Eric Fischer and Lyn Jones. The goals of the Center for Protein Degradation are to create a next-generation protein degrader platform and interrogate and advance a large portfolio of protein degrader targets. This is an exceptional opportunity to join a newly founded research center that is pushing the boundaries of targeted protein degradation research and accelerating the translation of basic science into novel therapeutic approaches.

    This individual will be an important member of our research team and will be centrally involved in assisting various research projects primarily involving chemical biology and protein biochemistry.



    Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.



    • Independently plan, manage, and perform experiments and identify next steps based on outcomes. Develop project proposals, timelines and resource needs.
    • Take a leading role in chemical biology at the center. Projects include hit generation, therapeutic target identification and drug-target engagement studies.
    • Purify recombinant proteins, and their complexes, from insect, mammalian or bacterial cells.
    • Conduct Cas9-based editing in mammalian cell lines as appropriate. Generate GFP/RFP stable mammalian cell lines (Lentiviral).
    • Conduct cellular/in-vitro assay optimization and compound screening.
    • Train research technicians and other scientific staff in methods/techniques and supervise on specific projects.
    • Communicate project progress to the group, and to leadership.
    • Interact and liaise with internal experts, external experts, academic groups, and CROs to establish and direct collaborations and projects.
    • Prepare papers and publications, as appropriate.



    • PhD degree in chemical biology or a related discipline. 2 years or more of relevant postdoctoral experience is preferred.
    • Strong experience in protein biochemistry, including recombinant protein expression, purification and biophysical characterization.
    • Familiarity with biophysical techniques used to assess interactions between proteins and proteins with small molecules (e.g. TR-FRET, FP, ITC, ELISA).
    • Experience in assay development and optimization (in-vitro and cellular, e.g. viability/ELISA/stable cell line/Cas9 editing).
    • Excellent communication and presentation skills.
    • Scientific drive, demonstrated by a proven track record of publications in peer reviewed journals
    • Ability to work independently as well as in a collaborative team environment
    • Excellent organizational and prioritization skills. Strong attention to detail.
    • Ability to collect and analyze experimental data, prepare research publications and communicate results.


    Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.


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