Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.
This is a postdoctoral research position using chemical approaches to solve biological problems. The lab's interests are in coming up with molecular solutions for the treatment and imaging of solid tumors, development of new antibiotics for gram-negative pathogens, and discovery of new inhibitors for protein-protein interactions. Synthetic chemists work very closely with chemical and molecular biologists in designing, synthesizing, and assaying molecules for their intended biological effects. Synthetic work will involve very basic science involving methodological development of new chemical reactions and synthetic strategies, compound library synthesis for screening, as well as complex molecule synthesis. Biological work will involve tissue culture, running compound assays, and include tandem mass spectrometry analysis of peptides. Candidates should have a strong background in relevant areas of chemistry or biology. For additional information see kimlab.dana-farber.org.
Ph.D. in organic chemistry, biochemistry, chemical biology, cancer biology or other relevant fields. Candidates applying with a more synthetic chemistry background should have experience in small molecule synthesis at the micromole to hundreds of millimole scale, in purification techniques using HPLC and flash chromatography, in analytic techniques such as mass spectrometry, NMR (1D and 2D, including HSQC, HMBC, NOESY, ROESY, etc.), UV/VIS, IR spectroscopy, and in both solution and solid-phase peptide synthesis. Those with a more biological background should have experience in microbiology including cloning, protein expression, and bacterial cell culture and/or have extensive experience in mammalian cell culture and running standard cell assays including viability and pharmacokinetics assays. Experience with hypoxia or tandem mass spectrometry on peptides is a plus. Candidates should be fluent in English with excellent oral and written communication skills.
Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.