• Bioinformatics Engineer I

    Location US-MA-Boston
    Job Posted Date 2 months ago(12/7/2018 1:15 PM)
    Job ID
    IT/Health IT/Informatics
    full time
  • Overview

    Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.


    The Center for Cancer Genome Discovery (CCGD) at Dana-Farber facilitates genomic discoveries in cancer using novel technology platforms to assist researchers in both genome-wide and gene-focused efforts. Technologies are selected and developed with a view to research-oriented ventures, as well as translational medicine and clinical relevance. The PROFILE program is a collaborative effort between Brigham and Women's Hospital, Dana-Farber Cancer Institute, and Boston Children's Hospital to advance precision cancer medicine by implementing tumor genomic profiling for cancer patients at these hospitals.  Some technologies deployed in PROFILE are developed in the Center for Cancer Genome Discovery (CCGD) at Dana-Farber. 


    Our clinical and research environments currently use state-of-the-art massively parallel sequencing assays of DNA and RNA from patient tumor samples. Data from these environments are used to advance research on both adult and pediatric cancers, improve our understanding of cancer biology, and advance the field of precision cancer medicine. This opportunity offers the chance to work at the forefront of translational cancer technologies and applications, in an informatics group that enables analyses in both arenas.



    The Bioinformatics Engineer will help develop, maintain, and refine CCGD’s bioinformatics capabilities for genome research in cancer. More specifically, he/she will work closely with CCGD scientists in the analysis and interpretation of next generation sequencing data for cancer research.  The Engineer will work closely with the lab scientists to provide analysis for CCGD’s collaborators.


    Additional duties may include, but are not limited to:


    * Identify opportunities and develop innovative solutions for analysis, integration, and representation of data from multiple next-generation sequencing (NGS) endpoints (DNA-seq, RNA-seq).

    * Evaluation of external and internally developed tools for analyzing NGS data.

    * Work closely with CCGD scientists in the design and analysis of research projects.

    * Provide direct technical and scientific support for CCGD investigators and staff. 


    Knowledge, Skills and Abilities Required


    * Understanding of genomics and molecular biology (cancer genomics and massively parallel sequencing a plus)

    * Strong communication skills and ability to effectively translate informatics concepts to multidisciplinary (non-informatics) personnel

    * Proficiency with programming languages such as Python or Java, statistical programming using R or related tools and queries through SQL required.  

    * Strong interpersonal skills and ability to effectively interact with all levels of staff and external contacts

    * Excellent analytical, organizational and time management skill



    * Bachelor’s degree required, MS preferred, in computer science and/or the life sciences and 0-2 years relevant experience.

    * Familiarity with principles of experimental design and modern data analysis paradigms is required.

    * Strong interpersonal skills and ability to effectively interact with all levels of staff and external contacts.

    * Excellent analytical, organizational and time management skills.


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