• Research Fellow

    Location US-MA-Boston
    Job Posted Date 1 year ago(11/29/2018 3:01 PM)
    Job ID
    full time
    Location : Address
    450 Brookline Ave
    Location : City
  • Overview

    Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.


    The Fischer Lab at Dana-Farber Cancer Institute is a Structural Biology Lab that combines molecular biology, computational biology, structural biology and chemistry with various ‘Omics’ techniques such as proteomics to study the pathways and protein complexes involved in the regulation of protein abundance via cellular degradation systems that are often associated with human diseases, including cancer. Using our knowledge of the cellular degradation machinery, we use structure and computational guided approaches to develop new molecules that hijack the ubiquitin proteasome system for targeted protein degradation.

    The Fischer Lab (https://fischerlab.dana-farber.org/) seeks a highly motivated individual to join the team as a POSTDOCTORAL RESEARCH FELLOW who will work on various mass spectrometry-based proteomics projects such as:

    • Targeted detection of proteins and post-translational modifications
    • Cross-linking mass spectrometry for studying protein structure and protein-protein interactions
    • Deep shotgun proteomics of whole cell proteomes


    Our laboratory is based at Dana-Farber Cancer Institute in Longwood Center and is an affiliate of the BCMP department at Harvard Medical School, and part of Dana-Farber’s Center for Protein Degradation. Join our highly interactive team of scientists, postdocs, graduate students and technicians to work on testing and creating new avenues of therapeutic intervention.


    • Proteomics-based method development
    • Analyze experimental data and interpret results to write reports, presentations, grant and publication preparation
    • Maintains detailed notebook of all work-related activities
    • Collaborates with other lab members for the development, modification and improvement of standard operating procedures


    • Recent Ph.D. or equivalent degree
    • Good understanding of statistics
    • Experience in sample preparation for mass spectrometry-based proteomics
    • Ability to collect and analyze experimental data, prepare research publications and communicate results
    • Ability to work in a collaborative and team environment
    • Experience with R, MATLAB, python and general computational abilities


    Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.



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