• Research Technician - Translational Immunogenomics Lab

    Location US-MA-Boston
    Job Posted Date 4 weeks ago(5/23/2019 4:20 PM)
    Job ID
    Research- Laboratory
    full time
  • Overview

    The Dana Farber Cancer Institute brings together world-renowned clinicians, innovative researchers and dedicated professionals, allied in the common mission of conquering cancer. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to all patients; we conduct research that advances treatment; we educate tomorrow’s physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.


    The Translational Immunogenomics Lab (TIGL) within DFCI uses state-of-the-art genomic technologies to assess the response of the immune system to cancer and therapy. TIGL evaluates the latest developments in the field, implements the optimal methods for the task at hand, and invents methods when current approaches are inadequate. The current focus of TIGL is discovering patient-specific neoantigens, understanding the details and consequences of interactions between neoantigens and T cells, and applying this knowledge to support neoantigen immunization therapy.



    A full-time position is available for a highly motivated research technician to examine immune responses in personalized neoantigen based cancer vaccines (Ott, Hu, Keskin et al. Nature 2017), including how cancer cells evade the immune system. The laboratory uses a variety of cutting edge immunological, biochemical, cell biology, and translational approaches to identify new therapeutic targets and develop preclinical models. The technician will be responsible for cell culture and flow cytometry of patient samples collected in the clinical trials, and thus the candidate should have meticulous record keeping and organizational skills. This position will require comfort and ease with cell culture and flow cytometry of patient blood samples. In addition, the candidate will likely learn immunological techniques such as ELISPOT, ELISA assays, basic handling of DNA and RNA, including PCR, and flow cytometry. Training is available in all procedures; some experience in the above techniques is preferred.


    • Set up, adjust, calibrate, clean, maintain and troubleshoot equipment.
    • Clean, maintain and prepare supplies and work areas and may be responsible for ordering of supplies. Collaborates with Purchasing and may be responsible for negotiating with vendors.
    • Conduct standardized biological, microbiological or biochemical tests and laboratory analyses, including the collection of information and samples from organic substances, such as blood, drugs, and animals.
    • Isolate, identify and prepare specimens for examination.
    • Analyze experimental data and interpret results to write reports and summaries of findings, including grant preparation and presentations, and look for opportunities to co-author publications. May be expected to participate in formal and information presentations of results to staff. 
    • Participate in grant application process and manuscript preparation as required.
    • Maintains detailed notebook of all work-related activities.
    • Monitors laboratory work to ensure compliance with Environmental Health and Safety information as well as the standard operation procedures specific to each laboratory.
    • Expected to provide intellectual and interactive commitment to position by keeping up with appropriate literature and research publications.
    • May be responsible for the development, modification and improvement of standard operating procedures.
    • Uses computers, computer-interfaced equipment, robotics or high-technology applications to perform work duties.
    • May be responsible for designing and executing advanced experiments and setting strategy. 
    • May be responsible for the examination of animals and specimens to detect the presence of disease or other problems.
    • May be responsible for monitoring laboratory budgets.



    • Bachelor's Degree required with a major in biology or chemistry preferred. 
    • Some previous laboratory experience, specifically cell culture and/or flow cytometry, is required.
    • Knowledge of information and techniques related to either biology, chemistry, or medicine is preferred.
    • Must have excellent communication skills (written and verbal) and be able to work with a wide variety of faculty and staff.
    • Ability to analyze information and use logic to address work-related issues and problems.
    • Must have attention to detail and be thorough in completing work tasks.
    • Ability to work within a team environment.

    We are looking for candidates who have at least two years of availability


    Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.


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